Leena Alhonen Selected Research

Putrescine

9/2012	Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.
1/2011	Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.
9/2010	Polyamines and hair: a couple in search of perfection.
1/2009	Changes in blood polyamine levels in human acute pancreatitis.
7/2008	A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.
1/2008	Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis.
10/2005	Animal disease models generated by genetic engineering of polyamine metabolism.
3/2005	Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.
10/2003	Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
9/2002	Gene dosage of the spermidine/spermine N(1)-acetyltransferase ( SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD).

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Leena Alhonen Research Topics

Disease

15	Neoplasms (Cancer) 12/2018 - 04/2003
14	Pancreatitis 02/2012 - 10/2002
5	Acute Necrotizing Pancreatitis 02/2012 - 01/2008
5	Insulin Resistance 01/2011 - 10/2006
4	Type 2 Diabetes Mellitus (MODY) 04/2014 - 07/2007
4	Obesity 04/2014 - 07/2007
4	Inflammation (Inflammations) 01/2014 - 04/2007
3	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 06/2005
3	Hepatolenticular Degeneration (Wilson's Disease) 01/2016 - 08/2010
3	Carcinoma (Carcinomatosis) 01/2016 - 02/2010
3	Carcinogenesis 09/2012 - 03/2004
3	Necrosis 01/2011 - 07/2008
3	Glioma (Gliomas) 06/2006 - 04/2003
2	Breast Neoplasms (Breast Cancer) 01/2016 - 02/2012
2	Hypertrophy 10/2010 - 03/2004
2	Reperfusion Injury 07/2010 - 04/2009
2	Alzheimer Disease (Alzheimer's Disease) 01/2010 - 12/2004
2	Epilepsy (Aura) 02/2007 - 10/2003
1	Choriocarcinoma 01/2016
1	Myeloid Leukemia (Leukemia, Myelocytic) 07/2014
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2014
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2014
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2014
1	Neural Tube Defects (Exencephaly) 03/2014
1	Fetal Alcohol Spectrum Disorders 03/2014
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 03/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2014
1	Hepatocellular Carcinoma (Hepatoma) 09/2012
1	Acute-Phase Reaction 02/2012
1	Hyperthyroidism 01/2011
1	Lung Injury 01/2011
1	Cushing Syndrome 01/2011
1	Atherosclerosis 01/2011
1	Cardiomegaly (Heart Hypertrophy) 10/2010
1	Myocardial Ischemia (Ischemic Heart Diseases) 10/2010
1	Hirsutism 09/2010
1	Acute Kidney Injury (Acute Renal Failure) 07/2010

Drug/Important Bio-Agent (IBA)

40	PolyaminesIBA 01/2016 - 10/2002
22	SpermidineIBA 01/2016 - 10/2002
18	SpermineIBA 07/2014 - 10/2002
10	EnzymesIBA 01/2016 - 03/2004
10	PutrescineIBA 09/2012 - 09/2002
9	diamine N-acetyltransferase (spermidine acetyltransferase)IBA 07/2014 - 09/2002
4	Glucose (Dextrose)FDA LinkGeneric 01/2011 - 10/2006
4	Taurodeoxycholic AcidIBA 01/2011 - 01/2008
3	Trientine (Trien)FDA Link 01/2016 - 02/2010
3	AcetyltransferasesIBA 01/2014 - 04/2009
3	N(1),N(11)-diethylnorspermineIBA 02/2012 - 02/2002
3	Proteins (Proteins, Gene)FDA Link 02/2010 - 03/2004
2	acetylaminophenylarsine oxideIBA 01/2018 - 09/2012
2	CopperIBA 01/2016 - 01/2013
2	Chelating AgentsIBA 01/2016 - 01/2013
2	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2016 - 09/2012
2	Oxidoreductases (Dehydrogenase)IBA 09/2012 - 08/2010
2	TrypsinogenIBA 11/2011 - 01/2006
2	Arginine (L-Arginine)FDA Link 11/2011 - 01/2006
2	OrnithineIBA 11/2011 - 10/2010
2	Amyloid (Amyloid Fibrils)IBA 01/2010 - 12/2004
2	Amylases FDA Link 07/2008 - 01/2008
2	alpha-AmylasesIBA 11/2007 - 10/2002
1	Biogenic PolyaminesIBA 12/2018
1	tetrathiomolybdate (ammonium tetrathiomolybdate)IBA 01/2016
1	Penicillamine (Cuprimine)FDA Link 01/2016
1	NAD (NADH)IBA 04/2014
1	N-nitroso-N-methyltyramine (NNMT)IBA 04/2014
1	Histones (Histone)IBA 04/2014
1	Nicotinamide N-MethyltransferaseIBA 04/2014
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 04/2014
1	Sirtuin 1IBA 04/2014
1	Ethanol (Ethyl Alcohol)IBA 03/2014
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2014
1	Estrogen ReceptorsIBA 02/2012
1	Estradiol (Delestrogen)FDA LinkGeneric 02/2012
1	Estrogens (Estrogen)FDA Link 02/2012
1	LipopolysaccharidesIBA 02/2012
1	ZincIBA 02/2012
1	Basic Amino Acids (Basic Amino Acid)IBA 11/2011
1	Lysine (L-Lysine)FDA Link 11/2011
1	Transcription Factors (Transcription Factor)IBA 11/2011
1	AntioxidantsIBA 11/2011
1	Indicators and Reagents (Reagents)IBA 01/2011
1	trypsinogen activation peptideIBA 01/2011
1	TrypsinIBA 01/2011
1	Blood Glucose (Blood Sugar)IBA 01/2011
1	Caspase 3 (Caspase-3)IBA 01/2011
1	LipidsIBA 01/2011
1	Insulin (Novolin)FDA Link 01/2011
1	human VEGFB proteinIBA 10/2010
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2010
1	Placenta Growth FactorIBA 10/2010
1	Protein Isoforms (Isoforms)IBA 10/2010
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2010
1	Neuropilin-1IBA 10/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2010
1	Vascular Endothelial Growth Factor BIBA 10/2010
1	AminesIBA 09/2010
1	EndotoxinsIBA 07/2010
1	Polyamine OxidaseIBA 07/2010

Therapy/Procedure

4	Therapeutics 07/2014 - 04/2003
1	Chemoprevention 01/2016